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REBOUND PAIN AFTER PERIPHERAL NERVE BLOCKS

Investigation of the Frequency and Causes of Rebound Pain Phenomenon After Peripheral Nerve Blocks

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05635383
Enrollment
386
Registered
2022-12-02
Start date
2022-08-01
Completion date
2024-03-12
Last updated
2024-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Block, Pain

Keywords

REBOUND PAIN, PERIPHERAL NERVE BLOCKS, analgesia

Brief summary

In recent years, the use of regional anesthesia techniques as part of multimodal analgesia strategies to maximize pain control in patients has reduced opioid requirements and promoted early mobility and rehabilitation in the perioperative period. Regional anesthesia has benefits, mainly peripheral nerve blocks (PNB), muscle relaxation, and postoperative analgesia, thus allowing for control of postoperative pain and early discharge from the hospital. In addition, using PNB techniques provides: Hemodynamic stability. Reduced need for a post-anesthetic care unit (PACU). Reduced unplanned hospitalization for pain control. Less airway management. Reduced incidence of opioid-related adverse events. Greater patient satisfaction The main feature of rebound pain is that it is severe pain, within 8-24 hours after PNB. It usually remains severe for 2-6 hours, but the subsequent pain trajectory is consistent with the recovery process expected at surgical intervention. Therefore, rebound pain is temporary and different from persistent post-surgical pain (PPSP). Rebound pain often occurs at night. However, this is probably related to the 8 to 12-hour duration of most single-injection PNBs and the completion of most elective surgeries during daylight hours.

Detailed description

This study aims to reveal the rebound pain profile, determine the risk factors, and contribute to developing strategies that can prevent rebound pain.

Interventions

OTHERPERIPHERAL NERVE BLOCK

Observation of rebound pain after peripheral nerve block application

Sponsors

Diskapi Yildirim Beyazit Education and Research Hospital
Lead SponsorOTHER_GOV

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No

Inclusion criteria

* Patients aged \>18 years who underwent orthopedic surgery with the peripheral nerve block

Exclusion criteria

* Patients who did not want to participate in the study * dementia * severe psychiatric or cognitive dysfunction * coagulopathy * neuropathic disorder * local anesthetic allergy * serious heart-lung disease * chronic opioid use

Design outcomes

Primary

MeasureTime frameDescription
incidence of rebound painperioperative periodRebound pain-defined as transient acute postoperative pain within 12-24hrs that ensues following resolution of sensory blocked.

Secondary

MeasureTime frameDescription
rebound pain risk factorsperioperative periodsuch as age, gender, and presence of preoperative pain.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026