Change in MAPSE During Treatment of Sepsis

Evaluation of Mitral Annulus Systolic Plane Excursion (MAPSE) in Emergency Department Patients With Sepsis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05634733

Enrollment

Registered

2022-12-02

Start date

2023-04-01

Completion date

2030-12-01

Last updated

2025-06-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

POCUS, Emergency Department, echocardiography

Brief summary

Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may include obtaining ultrasound images and making measurements about how well or poorly the heart is pumping. The investigators will evaluate a certain measurement that relates to cardiac function, determine how it changes in patients before and after they are treated for septic shock. This will involve placing an ultrasound probe on the patient's chest, measuring the upward and downward movement of the mitral valve, the mitral annulus systolic plane excursion (MAPSE), and comparing the measurements before and after treatment is started. The investigators are attempting to determine if this measurement improves before and after treatment.

Interventions

OTHERTreatment of Sepsis

Patients will have standard care of sepsis

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of Sepsis or Septic Shock

Exclusion criteria

* Age equal to or less than 17 * patient in the emergency department * Unable to perform POCUS exam due to medical necessity * Patients without sepsis * unable to obtain consent or have a legal representative consent

Design outcomes

Primary

Measure	Time frame	Description
Change in MAPSE measurement	1 hour after treatment initiation	Does the MAPSE change after treatment of MAPSE

Countries

United States

Contacts

Primary ContactAlexis Salerno, MD

alexis.salerno@som.umaryland.edu(667) 214-2208

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026