Pituitary Tumors
Conditions
Brief summary
DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.
Interventions
OTHERno interventions between two groups
no interventions between two groups
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* 1\) histologically confirmed PAs, 2) Non-function pituitary adenomas
Exclusion criteria
* 1\) Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Residual tumor size | 1 week after surgery | Tumor size was evaluated by postoperative MRI |
| tumor recurrence | three years | During the follow-up, the tumor recurrence was observed closely |
Countries
China
Contacts
Primary ContactWu Qun
Outcome results
None listed