Pruritus
Conditions
Brief summary
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.
Detailed description
Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied
Interventions
DIETARY_SUPPLEMENTUremic pateints with itching
Activated charcoal
Sponsors
Benha University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients will take activated charcoal for two months
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Patients with end-stage renal failure with itching undergoing regular hemodialysis
Exclusion criteria
Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Severity of itching | Two months | Change of severity of itching by The Visual Analogue Scale score |
Countries
Egypt
Outcome results
None listed