Changes of Soft Tissue Grafting: A Randomized Study

Volumetric Changes of Soft Tissue Grafting. Comparison of Autologous PRF (Platelet-rich Fibrin ) & Autogenous CTG (Connective Tissue Grafts) . A Split-mouth Randomized Design

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05633511

Enrollment

Registered

2022-12-01

Start date

2023-01-11

Completion date

2036-12-30

Last updated

2026-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Brief summary

To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.

Detailed description

Patients that are interested in having corrective surgery for recession due to esthetic concerns or sensitivity will be enrolled in the study. The treatment site will randomly receive the procedure assignment. Intraoral scanner will be utilized to establish pre-op volume and will be repeated at each follow up visit. Total of 12 visits and 5 year duration is anticipated for the study.

Interventions

PROCEDURESplit Mouth Design

PRF on one side of mouth and CTG on the other side of participant's mouth.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults 18yrs or older 2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification) 3. Class A +/- 4. No class V restoration present

Exclusion criteria

1. Patients who do not consent to recommended therapy 2. Patients who smoke 3. Patients who will not be able to comply with follow up protocols 4. Those who self report that they are pregnant.

Design outcomes

Primary

Measure	Time frame	Description
Compare autologous PRF & Autogenous CTG	5 years	Primary objective of this study is to compare in a split-mouth study the effectiveness of CTG vs. PRF in soft tissue augmentation and volume stability of each treatment modality in correcting the Cairo Class I, II defects in Periodontally affected patients

Countries

United States

Contacts

CONTACTTannaz Shapurian, DDM, MSc

Tannaz.shapurian@tufts.edu617.636. 6741

CONTACTAnn-Marie Jacobson

ann-marie.billig@tufts.edu6176363751

PRINCIPAL_INVESTIGATORTannaz Shapurian, DMD, MSc

Tufts University School of Dental Medicine

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 30, 2026