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Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery

Retrospective Comparison of the Effects of Granisetron and Aprepitant in the Prevention of Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery

Status
UNKNOWN
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05632224
Acronym
PONV
Enrollment
60
Registered
2022-11-30
Start date
2022-11-24
Completion date
2023-01-31
Last updated
2022-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea, Vomiting

Keywords

postoperative nausea and vomiting, laparoscopic surgery

Brief summary

The goal of this clinical trial is to compare frequency with postoperative nausea and vomiting in ASA( American Society of Anesthesiologists) I, II patients undergoing laparoscopic surgery. The main question\[s\] it aims to answer are: * Primary Outcome is the incidence of nausea and vomiting between 0-6 and 6-24 hours postoperatively and the need for additional antiemetics * Secondary outcome is detection of additional analgesic needs and complications between 0-6 and 6-24 hours postoperatively. Participants will receive aprepitant or granisetron for prevention of postoperative nausea and vomiting.

Detailed description

The aim of this study is to investigate the effectiveness of drugs used for postoperative nausea and vomiting in laparoscopic surgeries. In the research; During the operation, the patient's vitals will be recorded intraoperative forms. Vitals are; heart rate, blood pressure, oxygen saturation, end tidal carbon dioxide levels; according to the pain level after awakening from the patient follow-up forms in the service. The doses and times of analgesics will be screened, the frequencies of postoperative nausea, retching, vomiting, and additional antiemetic doses will be screened, respiratory depression, complications of anesthesia, arrhythmia, laryngospasm, hypo-hypertension, headache, dizziness, allergic reactions anxiety symptoms will be screened too. we will try to emphasize which antiemetic is more effective than the other and which one has few side effects

Interventions

DRUGAprepitant

The drug is given 1 hour before the start of the surgery

DRUGGranisetron

The drug is given 10 minutes before the patients's extubation

Sponsors

Baskent University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Intervention model description

group 1:patient who receive aprepitant group 2: patient who receive granisetron

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes

Inclusion criteria

* ASA I, II patients patients undergoing laparoscopic surgery

Exclusion criteria

* ASA III and above patients who refused to participate in the study

Design outcomes

Primary

MeasureTime frameDescription
incidence of nauseapostoperative 24 hoursthe incidence of nausea between 0-6 and 6-24 hours postoperatively
the need for additional antiemeticspostoperative 24 hoursthe need for additional antiemetics between 0-6 and 6-24 hours postoperatively
incidence of vomitingpostoperative 24 hoursthe incidence of vomiting between 0-6 and 6-24 hours postoperatively

Secondary

MeasureTime frameDescription
additional analgesic needpostoperative 24 hoursDetection of additional analgesic needs between 0-6 and 6-24 hours postoperatively.
detection of complicationspostoperative 24 hoursdetection of complications between 0-6 and 6-24 hours postoperatively.

Countries

Turkey (Türkiye)

Contacts

Primary ContactBegüm Ne Gökdemir, MD
begokdemir@gmail.com+905389598290
Backup ContactNedim Çekmen, Professor
nedimcekmen@yahoo.com+905307384682

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026