Periodontal Diseases, Periodontal Pocket, Periodontal Bone Loss, Periodontal Attachment Loss
Conditions
Keywords
Periodontitis, Manuka honey, Periodontal pocket depth
Brief summary
The goal of this split-mouth clinical trial is to evaluate the effects of Manuka honey applied into periodontal pockets after initial periodontal therapy (NSPT) in the treatment of stage 3 periodontitis. The main question it aims to answer is: • does the adjunct of Manuka honey improve the outcome of the non-surgical periodontal treatment. The intervention in this study was conducted in a split-mouth design, meaning that after completing the NSPT for each subject, Manuka honey was administered as an adjunct to the periodontal treatment in two randomly selected quadrants of the oral cavity around the teeth with a specially designed cannula. This was followed by oral hygiene instructions and training. The home-performed oral hygiene procedures were focused on interdental cleaning using dental floss and toothbrushing with regular fluoride-containing toothpaste. The subjects were also instructed not to use any form of oral antiseptic (e.g., chlorhexidine) or antibiotic during the follow-up period.
Interventions
BIOLOGICALManuka honey
The honey was applied with special designed cannula. The dosage is not exactly define so we inject the amount of honey until until the excess of the material was observed in the sulcus.
Sponsors
University of Zagreb
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Split-mouth study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients of both genders with good systemic health; * Non-smokers; * Presence of at least 20 teeth; * Untreated moderate to advanced generalized chronic periodontitis according to the 1999 Classification 199 , i.e., generalized stage III periodontitis according to the 2007 Classification
Exclusion criteria
* Pregnant and nursing women; * Antibiotics prescribed for dental or non-dental diseases 6 months before the start of the research; * Systemic diseases or the use of drugs known to affect periodontal tissues, bleeding parameters; * Acute oral or periodontal inflammation or infection (pericoronitis, necrotizing periodontal diseases, etc.).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Periodontal pocket depth | Baseline; 12 months | Evaluation of changes of periodontal pocket depth |
| Clinical attachment level | Baseline: 12 months | Evaluation of changes in terms of clinical attachment gain |
Countries
Croatia
Outcome results
None listed