Severe Dengue
Conditions
Keywords
Severe Dengue, Dexamethasone, Steroid
Brief summary
The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.
Interventions
DRUGDexamethasone
Patients treated with dexamethasone
DRUGPlacebo
Patients treated with placebo
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
7 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test) * And still in febrile phase (Body temp\>37.5 C) * Shock : Sys\<90mmHg or Narrow PP (\<20mmHg) orTachycardia (pulse\>100/min) with Hematocrit decreased ≥20 % * Fluid accumulation and respiratory distress * Severe bleeding * Severe organ involvement
Exclusion criteria
* Severe dengue\> 24 hrs * Dengue without warning signs * Pregnancy * Patient who receieved any steroid within 1 week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 28 days | The use of steroids in dengue will reduce mortality in rate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | 28 days | The use of steroids in dengue will reduce Length of hospital stay in day |
Countries
Thailand
Outcome results
None listed