Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Conditions
Keywords
Bronchoalveolar Lavage, Noninvasive Mechanical Ventilation, Continuous Positive Airway Pressure, Bronchoscopy
Brief summary
The objective of our project is to find procedures and/or parameters to predict the diagnostic recovery (≥ 60% of the administered fluid volume) of bronchoalveolar lavage (BAL) fluid before bronchoscopy and to assess the impact of using non-invasive mechanical ventilation (NMV) or continuous positive airway pressure (CPAP) to achieve diagnostic recovery in patients with chronic obstructive pulmonary disease (COPD) and interstinal lungs disease for whom BAL performed during ordinary bronchoscopy turns out to be non-diagnostic.
Interventions
PROCEDUREBAL + PAP
May noninvasive mechanical ventilation (NIV) and/or continuous positive airway pressure (CPAP) increase the bronchoalveolar lavage (BAL) salvage in patients with pulmonary diseases?
Sponsors
Medical University of Silesia
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with diagnosed stable COPD (Stages 1-3) - experimental group; Patients with interstitial lung disease - experimental group 2. Former and current smokers with normal lung function - potential control group 1; 3. Never-smokers with normal lung ventilation - potential control group 2.
Exclusion criteria
1. No written, informed consent to participate in the research project. 2. Severe respiratory failure (SaO2 \< 90%) 3. The patient qualified for home oxygen treatment or home mechanical ventilation 4. Severe heart failure (NYHA class IV) 5. COPD mMRC IV 6. Myocardial infarction in the last two weeks or unstable angina 7. Severe, particularly ventricular arrhythmias 8. Platelet count \< 20,000/ul 9. INR \> 2 or APPT \> 36 sec 10. Very severe obstruction: forced expiratory volume in 1 second (FEV1) \< 30% of predicted.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| May noninvasive mechanical ventilation (NIV) and/or continuous positive airway pressure (CPAP) increase the bronchoalveolar lavage (BAL) salvage in patients with pulmonary diseases? | 3 years | Comparison of fluid recovery with BAL with and without NIV connection |
Countries
Poland
Contacts
Primary ContactAnna Danel, Medical Doctor
Outcome results
None listed