A Scalp Lotion Toimprove Sensitive Scalp Syndrome

Soothing and Anti-hair Loss Activity of a Scalp Lotion Containing Piroctone Olamine, 2,4 Diaminopyrimidine Oxide and Vichy Mineralizing Water

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05630027

Enrollment

100

Registered

2022-11-29

Start date

2019-01-02

Completion date

2020-06-30

Last updated

2022-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia, Sensitive Skin

Keywords

alopecia, sensitive skin, prurit

Brief summary

Overall, 100 Caucasian subjects participated in this 6-weeks lasting study, AC5+ was applied daily. All subjects had clinically confirmed mild to moderate alopecia and self-declared sensitive scalp. Instrumental assessments included Trans Epidermal Water Loss (TEWL), inflammation markers, clinical assessments included the severity of erythema, inflammation and greasiness. Subjective/Self assessments comprised the intensity of the scalp itch/pruritus and the evaluation of their head hair status (volume, abundance, strength). Same assessments were provided by the investigators.

Interventions

OTHERPiroctone Olamine (PO), 2,4 Diaminopyrimidine oxide (2.4 DA) and Vichy mineralizing water

observational, prospective study

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Inclusion criteria

* \>18 years * mild alopecia: * female: Ludwig type 1 * male: Hamilton III to IV type

Exclusion criteria

* Moderate or severe alopecia * Dandruff

Design outcomes

Primary

Measure	Time frame	Description
erythema	Baseline	on a scale from o=none to 5=severe
inflammation	Baseline	on a scale from o=none to 5=severe
greasiness	Baseline	on a scale from o=none to 5=severe
Global soothing score	Baseline	sum of the symptoms with a score up to 15

Secondary

Measure	Time frame	Description
pruritus	Baseline	on a scale from o=none to 5=severe
burning	Baseline	on a scale from o=none to 5=severe
Transepidermal water loss	Baseline	instrumental measurements
scratching	Baseline	on a scale from o=none to 5=severe
hair quality	Baseline	on a scale from o=none to 5=severe
stinging	Baseline	on a scale from o=none to 5=severe
Inflammation markers	Baseline	skin swabs analysis
squalene	Baseline	skin swabs analysis skin swabs analysis
Squalene monohydroperoxide	Baseline	skin swabs analysis

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026