Acute Cor Pulmonale, Acute Respiratory Distress Syndrome
Conditions
Brief summary
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
Interventions
PROCEDUREmechanical ventilation strategy guided by transpulmonary pressure
Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.
Sponsors
Beijing Chao Yang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* duration of invasive mechanical ventilation less than 72 hours; * meet the diagnostic criteria of Berlin definition for ARDS; * age older than 18
Exclusion criteria
* esophageal surgery or damage; * cardiac surgery; * severe bronchopleural fistula; * serious arrhythmia; pneumothorax; * tricuspid stenosis; * heparin allergy; * chronic pulmonary heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary vascular resistance (PVR) | 3 days | PVR will measured by Swan-Ganz catheter |
| Pulmonary vascular compliance | 3 days | Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter. |
Countries
China
Outcome results
None listed