Acne Vulgaris
Conditions
Brief summary
the goal of this clinical trial is to measure the efficacy of probiotics for treatment of acne vulgaris, to compare it with azithromycin and to measure the synergistic effect of azithromycin and probiotics for treatment of acne vulgaris
Detailed description
this study aims to answer this research question: in patients of acne vulgaris, is use of probiotics as efficacious as azithromycin in treating acne lesions & improving quality of life? total 75 patients were divided into 3 groups. group A received azithromycin, group B received probiotics and group C received both drugs. a topical cream was also advised to all groups. outcome was measured as reduction in total lesion count and improvement in patients' quality of life via reduction in Dermatology Life Quality Index score.
Interventions
DRUGAzithromycin
antibiotic
probiotics
DRUGBenzoyl Peroxide 4 % Topical Cream
topical cream
Sponsors
Pak Emirates Military Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed Patients of Mild and Moderate acne * Aged between 15 and 35 years
Exclusion criteria
* Severe acne or any systemic inflammatory disease * Other oral treatment for acne * Allergic to any drug being used in the study * Pregnancy * PCOs * Any drug which can interact with azithromycin
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change or reduction in the Total Lesion Count | at start of the study (baseline), 2 weeks (1st follow up visit), 4 weeks (2nd follow up visit), 8 weeks (3rd follow up visit) and 12 weeks (4th follow up visit). | number of acne lesions are counted at every follow up to see whether lesions are reduced than the baseline or not |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change or reduction in the Dermatology Life Quality Index score | at start of the study (baseline) and 12 weeks (last follow up visit). | improvement in patients' quality of life was assessed to see whether the score has been reduced than the baseline score or not. it was assessed by a 10-item self assessment questionnaire i.e Dermatology Life Quality Index. the score ranges between 0 to 30. higher score means worst outcome and the lower score means better outcome. |
Countries
Pakistan
Outcome results
None listed