Breast Feeding, Gestational Diabetes, Lipid Metabolism Disorders
Conditions
Brief summary
Breastfeeding could effectively be associated with a lower risk of future type 2 diabetes (T2D) in women with gestational diabetes mellitus (GDM), but the short-term protective impact of puerperal breastfeeding on maternal metabolic recovery of GDM women remains unascertained. The investigators recruited GDM participants at 6-9 weeks postpartum and retrieved clinical diagnoses of GDM from electronic medical records. Feeding patterns were collected via phone calls. Glucose metabolism parameters and lipid profiling were performed on fasting plasma samples collected from patients 6-9 weeks postpartum (20 breastfeeding cases vs. 15 formula feeding cases).
Interventions
OTHERobserve
no intervention
Sponsors
Nanjing Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
1. 18-35 years old; 2. gestational age greater than 37 weeks; 3. Body Mass Index (BMI) before pregnancy 18.5-28kg/m2; 4. Have normal listening and speaking skills, can communicate, and are willing to participate in this study.
Exclusion criteria
1. abnormal glucose metabolism or diabetes has been diagnosed before pregnancy; 2. assisted reproduction; 3. GDM patients requiring drug treatment; 4. The use of blood lipid regulation drugs; 5. other pregnancy complications and complications; 6. Suffering from heart, malignant tumor, kidney and other major organ diseases; 7. associated with neurological dysfunction and cognitive impairment; 8. Failure to cooperate with follow-up observers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| glucose | At 6-8 weeks postpartum | glucose (mmol/L) determined with human ELISA kits |
| insulin | At 6-8 weeks postpartum | insulin (mU/L) determined with human ELISA kits |
| c-peptide | At 6-8 weeks postpartum | c-peptide (ng/m) determined with human ELISA kits |
| HOMA-IR | At 6-8 weeks postpartum | fasting glucose and fasting glucose will be combined to report HOMA-IR |
Countries
China
Outcome results
None listed