Carotid Artery Stenosis
Conditions
Keywords
carotid artery stenosis, Perfusion, plaque, MRI, CT, PET/MRI, Ultrasound
Brief summary
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy. The main questions it aims to answer are: * Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion. * Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques. Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.
Interventions
PROCEDURECarotid revascularization
All patients received carotid revascularization surgery at Peking Union Medical College Hospital.
DIAGNOSTIC_TESTMRI-PWI
Multi-modal MRI before and after surgery.
DIAGNOSTIC_TESTCTA
CTA before and after surgery.
DIAGNOSTIC_TESTPET/MRI
PET/MRI before surgery.
DIAGNOSTIC_TESTUltrasound
Ultrasound before and after surgery.
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram; 2. patients received carotid endarterectomy at Peking Union Medical College Hospital
Exclusion criteria
(1) Any contraindication to image examination; (3) refuse to sign the Informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| death | During hospital stay, usually 7-30 days post operation | perioperative death |
| stroke | During hospital stay, usually 7-30 days post operation | perioperative stroke |
| cardiac infarction | During hospital stay, usually 7-30 days post operation | perioperative cardiac infarction |
| transient ischemic attack | During hospital stay, usually 7-30 days post operation | perioperative transient ischemic attack |
| cerebral hyperperfusion syndrome | During hospital stay, usually 7-30 days post operation | perioperative cerebral hyperperfusion syndrome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Image characters of PET/MRI | half year after operation | Diagnostic performance of 68Ga-FAPI PET/MR for intracranial or carotid atherosclerosis |
| Image characters of ultrasound | half year after operation | Diagnostic performance of carotid artery ultrasound for intracranial or carotid atherosclerosis |
| Carotid plaque characters | half year after operation | pathology characters of carotid plaque |
| Image characters of MRI | half year after operation | Arterial transit times, cerebral blood flow, plaque characters, etc. |
Countries
China
Contacts
Primary ContactZhichao Lai, MD
Outcome results
None listed