Healthy
Conditions
Brief summary
This is a single-center study at the Cleveland Clinic Main Campus designed to study biomarkers in healthy individuals to identify novel mechanisms of platelet activation and how platelets drive vascular inflammation and thrombosis in diseases.
Detailed description
Our past studies have discovered novel platelet activation pathways that may be targets of therapeutic development. We have also defined an important role for a shift in platelet phenotype in vascular disease. Our studies use both in vivo animal models and validation using human platelets from isolated blood. Platelets from healthy individuals may be compared to patients with vascular diseases in the IRB approved protocol Vascular Lab Resource (IRB #19-1451) study which is actively recruiting patients at the Cleveland Clinic Main Campus and studies patients with vascular diseases.
Interventions
None listed
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
The Cleveland Clinic
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* Adults aged 18 to 65 years old * Healthy Male & Female voluntary participants
Exclusion criteria
* Individuals who have taken anticoagulant or antiplatelet medications in past 10 days * Individuals with hematopoetic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To collect blood samples | 10 years | To establish a biorepository for normal healthy cohort of subjects |
Countries
United States
Contacts
Primary ContactScott Cameron, MD, PhD
Outcome results
None listed