Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio

The Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio in Patients Undergoing Forearm Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05628935

Enrollment

Registered

2022-11-29

Start date

2018-01-01

Completion date

2021-11-01

Last updated

2022-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Inflammation

Keywords

General Anesthesia, Neutrophil Lymphocyte Ratio, Peripheral Nerve Block

Brief summary

The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method. The method of anesthesia can affect NLR, thereby modulating the inflammatory response and surgical outcomes. In this study, it was aimed to evaluate the relationship between blood NLR and anesthesia techniques in patients undergoing forearm surgery, and the secondary aim was to evaluate the relationship between Platelet/lymphocyte ratio (TLR), Mean Platelet Volume (MPV) and anesthesia techniques.

Interventions

PROCEDUREperipheral nerve block

local anesthetic application to the brachial plexus

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Underwent forearm surgery * Between aged 18-70 * Under general anesthesia or peripheral nerve block

Exclusion criteria

* acute infection * morbid obesity * chronic treatment with steroids or immunosuppressants * recently received chemotherapy * hepatic and renal dysfunction; * chronic alcohol abusers * Multiple trauma * Patients with missing data in their files

Design outcomes

Primary

Measure	Time frame	Description
Neutrophil/lymphocyte ratio	up to 24 hours after surgery	Differences in neutrophil-lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block

Secondary

Measure	Time frame	Description
Platelet/lymphocyte ratio	up to 24 hours after surgery	Differences in Platelet/lymphocyte ratio between patients who underwent general anesthesia and peripheral nerve block
Mean Platelet Volume	up to 24 hours after surgery	Differences in Mean Platelet Volume between patients who underwent general anesthesia and peripheral nerve block

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026