Fluid Responsiveness, Septic Shock
Conditions
Brief summary
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness). After initial resuscitation by rapid fluid administration, cardiac preload is no longer extremely low and only half of the patients respond to further volume expansion with the expected increase in cardiac output (fluid unresponsiveness). However, the time delay or the volume of fluid needed to be administered from the state of fluid responsiveness to fluid unresponsiveness is still not determined. Objective To determine, in critically ill patients with acute circulatory failure, 1. : the time and/or the volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness during septic shock. 2. : determine the factors that influence this time and volume.
Interventions
None listed
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Bicetre Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 ans * Onset of septic shock
Exclusion criteria
* Planned to transfer the patient to another healthcare facility (inability to continue cardiac output measurements); urgent operation; Inability to measure the cardiac output.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The time delay from the state of fluid responsiveness to fluid unresponsiveness | 60 minutes after the evaluation of fluid responsiveness | At the time of inclusion, the investigators use the tests available (fluid challenge, passive leg raising, end-expiratory occlusion test) to evaluate the presence of fluid responsiveness, and after one hour, the investigators repeat the test and to re-evaluate the presence of fluid responsiveness until the patient is no longer present the fluid responsiveness. |
| The volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness | 15-30 minutes during the fluid administration | If the fluid challenge is performed, the volume of each time for the fluid administration should be noted until the patient is no longer fluid-responsive, then the investigators can calculate the total amount of the fluid administrated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The risk factors for the time delay | Through study completion, an average of 1 year | Determine the factors that may influence the time delay from the state of fluid responsiveness to fluid unresponsiveness |
| The risk factors for the volume of fluid needed from the state of fluid responsiveness to fluid | Through study completion, an average of 1 year | Determine the factors that may influence the volume of fluid administrated from the state of fluid responsiveness to fluid unresponsiveness |
Countries
France
Contacts
Primary ContactRui SHI, M.D., Ph.D.
Backup ContactXavier MONNET, M.D.,Ph.D.
Outcome results
None listed