Molecular Network Characteristics of Phlegm-heat Syndrome in Ischemic Stroke Based on Multi-omics Integrated Analysis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05626296

Enrollment

Registered

2022-11-23

Start date

2022-11-14

Completion date

2024-12-31

Last updated

2024-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke, Acute

Brief summary

The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data. The main purpose of this study is to validate the molecular characteristics and biomarkers of phlegm-heat syndrome in ischemic stroke, and to demonstrate the association of biomarkers with clinical outcomes.

Detailed description

This is a cohort study in patients with ischemic stroke. The demographic characteristics, TCM syndromes, and other baseline information will be recorded. At the same time, baseline peripheral blood will be collected. These participants will be followed up to 90 days of onset, and 90-day modified Rankin scale (mRS) scores will be assessed. The collected blood samples will be tested by multi-factor detection technology for candidate biomarkers.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Acute ischemic stroke, were confirmed by magnetic resonance imaging (MRI). * Symptom onset within 72 hours. * Diagnosis of phlegm-heat syndrome or non-phlegm-heat syndrome. * Male or female ≥ 50 years and ≤ 80 years. * With written informed consent.

Exclusion criteria

* Planned or already receiving intravenous thrombolysis or endovascular treatment. * Acute infectious diseases or acute exacerbations of chronic diseases within one month before enrollment. * Patients with previous stroke. * Renal or hepatic insufficiency, tumors, immune diseases, severe underlying diseases. * Other conditions that may affect the collection and evaluation of clinical information (e.g., severe aphasia, mental illness).

Design outcomes

Primary

Measure	Time frame	Description
Omic biomarkers associated with phelm-heat syndrome in ischemic stroke	baseline	Sensitivity, specificity, and area under the ROC curve of omic biomarkers of Phlegm-heat syndrome in ischemic stroke.

Countries

China

Contacts

Primary ContactXinxing Lai

new-star@163.com8615901111280

Outcome results