Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05626010

Enrollment

Registered

2022-11-23

Start date

2022-11-23

Completion date

2023-11-30

Last updated

2022-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Disease

Brief summary

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after thyroidectomy.

Detailed description

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after thyroidectomy. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed

Interventions

DRUGAcetaminophen

acetaminophen 1g iv dripping at end of surgery

DRUGIbuprofen

ibuprofen 300mg iv dripping at end of surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* the patients undergoing scheduled thyroidectomy * American Society of Anesthesiologists status 1 or 2

Exclusion criteria

* refusal to be enrolled in the study * emergency surgery * hepatic or renal disease * on chronic pain medications * psychiatric disorders * pregnancy, lactation * allergy or contraindication to the study drug

Design outcomes

Primary

Measure	Time frame	Description
postoperative pain	during 30 minutes after surgery	the maximal postoperative pain severity using pain scale(visual analogue scale; 0 cm=no pain; 10 cm=the worst pain)

Secondary

Measure	Time frame	Description
pain killer requirement	during 30 minutes after surgery	the incidence of the patients who require pain killer

Countries

South Korea

Contacts

Primary Contactyoungeun moon, MD, PhD

0910momo@naver.com822-2258-6163

Backup Contactjaesik park, MD

cmcanepm@catholic.ac.kr822-2258-6163

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026