Phonotrauma
Conditions
Brief summary
There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to varied phonation patterns, which will be addressed using the following two aims: Aim 1: Determine how CPP and H1-H2 change as a function of using pressed voice production in individuals without laryngeal pathology. Aim 2: Examine the sensitivity (minimally detectable change) and responsiveness (minimal clinically important difference) of CPP and H1-H2 to detect changes in different voice production conditions.
Interventions
DIAGNOSTIC_TESTAcoustic voice analysis
Acoustic recordings will involve the five repetitions of three vowels (/ɑ, i, u/) and a standard reading passage (Rainbow Passage) in different voice conditions. Control participants will produce voice in breathy, typical, and pressed conditions. Patient participants will produce voice in typical production and in a resonant voice production. High-speed videoendoscopy and simultaneous acoustic recording will occur on one repetition of a sustained /i/ in each requested condition. Data will be collected using a head-mounted microphone.
DIAGNOSTIC_TESTHigh-speed videoendoscopy
High-speed videoendoscopy will occur on one repetition of a sustained /i/ in each requested condition. Exams will be recorded using the Phantom V311 high-speed camera (Vision Research, Wayne, NJ) connected to a Storz 70° rigid laryngoscope using a 400 Watt Xenon light source (Titan 400E).
Sponsors
University of Texas Southwestern Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Control Group: Inclusion Criteria: 1. 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia) 2. No history of or current voice disorder 3. Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP).
Exclusion criteria
1. Atypical auditory-perceptual voice presentation 2. History of voice disorder or laryngeal surgery. Patient Group: Inclusion Criteria: 1. Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist. 2. 18-65 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cepstral Peak Prominence | 1 year | Cepstral peak prominence is a measure of the periodic energy of the acoustic voice signal. |
| The difference between the first and second harmonic (H1-H2) | 1 year | H1-H2 is a spectral measure derived from the acoustic voice signal that correlates with glottal configuration. |
| Average closing velocity | 1 year | Vocal fold closing phase velocity averaged across 100 vibratory cycles |
Countries
United States
Contacts
CONTACTLaura Toles, PhD
CONTACTPaula Arellano-Cruz
Outcome results
None listed