Diphosphonates
Conditions
Keywords
Bisphosphonates, Total joint arthroplasty, Revision surgery, Periprosthetic fracture
Brief summary
Background Bisphosphonates has been associated with a decreased risk of revision total joint replacements because of its effects on decreased periprosthetic bone loss and prosthetic migration. However, the results in the early literature are inconsistent and the influence of bisphosphonates on associated complications and subsequent total joint arthroplasty (TJA) remains unknown. This study is to investigate the association between the use of bisphosphonates and risk of adverse outcomes after primary TJA. Materials and Methods This matched cohort study utilized National Health Insurance Research Database in Taiwan to identify patients who underwent primary TJA over a 15-year period (January 2000- December 2015 inclusive). Study participants were further categorized into two groups: bisphosphonates users and nonusers, using propensity score matching. The Kaplan-Meier curve analysis and adjusted hazard ratios (aHR) of revision surgery, adverse outcomes of primary surgery and undergoing subsequent TJA were calculated using Cox regression analysis.
Interventions
DRUGBisphosphonates, Combinations
Sponsors
National Defense Medical Center, Taiwan
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Inclusion criteria
1. Patients who underwent primary total joint arthroplasty during the study period (January 1, 2000 to December 31, 2015).
Exclusion criteria
1. Patients with total joint arthroplasty before the index date, 2. Patients with existing pathologic fracture, nonunion of fracture and partial joint replacement, 3. Patients who were lost to follow-up 4. Patients \< 40 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| revision rate of joint arthroplasty | a 15-year period (January 2000- December 2015 inclusive) | revision rate of joint arthroplasty after primary surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The rate of secondary total joint arthroplasty | a 15-year period (January 2000- December 2015 inclusive) | The rate of secondary total joint arthroplasty |
| The rate of periprosthetic joint infection | a 15-year period (January 2000- December 2015 inclusive) | The rate of periprosthetic joint infection |
| The rate of periprosthetic fracture | a 15-year period (January 2000- December 2015 inclusive) | The rate of periprosthetic fracture |
| Mortality rate | a 15-year period (January 2000- December 2015 inclusive) | Mortality rate |
Countries
Taiwan
Outcome results
None listed