Breast Cancer
Conditions
Brief summary
This is a prospective and retrospective study to evaluate the effect of pre-operative therapy on response and survival, and compare the difference in response and survival by pre-operative regimen or by patient's clinicopathological characteristic in early or advanced breast cancer.
Interventions
DRUGpre-operative therapy
pre-operative therapy includes pre-operative chemotherapy, radiation, endocrine therapy, target therapy and other anti-tumor therapy
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Female, Aged ≥18 years * Histologically confirmed primary breast cancer * Plan to receive pre-operative therapy * Adequate organ function
Exclusion criteria
* History of neurological or psychological disease, including epilepsy or dementia * Not suitable to participate in this study judged by investigators
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pathologic Complete Response | at surgery | ypT0 ypN0, ypT0/is ypN0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Objective response rate | from the start of pre-operative treatment until the completion of surgery up to 6 months | the rate of complete response and partial response |
| Disease-free Survival | From surgery until time of event up to 8 years | Disease-free survival time is defined as the time from date of randomization until the first occurrence of disease recurrence, distant metastasis and death from any cause. |
Countries
China
Contacts
CONTACTWenjin Yin
Outcome results
None listed