Effects of Citrus Reticulate Unripe Fruit Extraction on Body Weight and Body Fat.

Effects of Citrus Reticulate Unripe Fruit Extraction on Body Weight and Body Fat in Human Trial.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05620667

Enrollment

300

Registered

2022-11-17

Start date

2022-10-28

Completion date

2023-08-31

Last updated

2022-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and Obesity

Brief summary

The aim of this study is to investigate the effects of immature ponkan (Citrus reticulate) extract on body weight and body fat in overweight and obese adults.

Detailed description

This randomized, placebo-controlled clinical trial will be conduct for 8 weeks with three hundred adults. Subjects will be recruited and randomly assigned into three groups: (1) placebo, n = 100; (2) immature ponkan extract, n=100; (3) immature ponkan extract with time restricted feeding, n=100. During the 8 weeks intervention, the subjects should take 25mL liquid of placebo or immature ponkan extract a day (drink 25mL for once, and once a day). The two drinks are supplied in aluminum foil packages, and both the products taste the same. Subjects also should complete the assessment of anthropometric measurement, intestinal questionnaire , food record, feces and blood collection at week 0, 4 and week 8.

Interventions

DIETARY_SUPPLEMENTimmature ponkan (Citrus reticulate) extract

Drink 25mL for once, and once a day.

DIETARY_SUPPLEMENTplacebo

Drink 25mL for once, and once a day.

BEHAVIORALtime restricted feeding

Controlling a shortened period of time for eating within 8 hour each day.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* male or female * aged 20-60 years old * body mass index is greater than or equal to 24 kg/m2, or body fat more than 30%

Exclusion criteria

* Subjects diagnosed with cancer and on curative care. * Subjects diagnosed with heart disease and on curative care. * Subjects who use other drugs whose pharmacological effects may affect the experiment or may aggravate the effects of the drug. * Subjects with systemic infection requiring antibiotics.

Design outcomes

Primary

Measure	Time frame	Description
Change from baseline body weight at week 8	Week 0, Week 8	Compared the difference of body weight between the week 8 and 0.

Secondary

Measure	Time frame	Description
Change from baseline body fat at week 8	Week 0, Week 8	Compared the difference of body fat between the week 8 and 0.

Countries

Taiwan

Contacts

Primary ContactChin-Lin Hsu, Professor

clhsu@csmu.edu.tw04-24730022

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026