Hypercholesterolemia, Lipid Disorder, Postprandial Hyperglycemia
Conditions
Keywords
mushroom, lipid metabolism, postprandial lipemia, postprandial glycemia
Brief summary
The goal of this clinical trial is to determine the acute effects on postprandial lipemia and glycemia by supplementing a high-fat meal with either white button (WB) or shiitake (SH) mushroom powder in relatively healthy adults, aged 18 to 35.
Interventions
DIETARY_SUPPLEMENTMushroom Powder
Ground shiitake mushrooms or ground white button mushrooms
Sponsors
State University of New York at Buffalo
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Double-blind, randomized
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* generally healthy * non-diabetic * normal to mildly hypercholesterolemic (Total Cholesterol 200-239 mg/dL and LDL-C 130-159 mg/dL) * have BMI \<30 or BF% (men \<25%, women \<32%) * no known disease of the liver or gallbladder * no documented problems with fat metabolism * normal lipemic response to a lipid challenge * No known mushroom allergy
Exclusion criteria
* diabetic * pregnant * BMI \>30 * liver disease * gallbladder disease * mushroom allergy * lipid disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial Lipemia | Baseline, up to 6 hours postprandial | Total cholesterol, LDL, HDL, triglycerides |
| Postprandial Glycemia | Baseline, up to 6 hours postprandial | blood glucose |
Outcome results
None listed