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CAR-T Cells in the Treatment of Malignant Hematological Tumors

Clinical Study of CAR-T Technique in the Treatment of Recurrent and Refractory Hematopoietic and Lymphatic Tumor

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05619861
Enrollment
20
Registered
2022-11-17
Start date
2020-04-27
Completion date
2023-12-26
Last updated
2022-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Leukemia, B-cell, Leukemia, T-Cell, Lymphoma, B-Cell, Multiple Myeloma

Keywords

T cells

Brief summary

To evaluate the safety of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors

Detailed description

Main research objective: To evaluate the safety of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors. Secondary research objective: To investigate the efficacy and cytodynamic characteristics of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors

Interventions

BIOLOGICALCAR-T

Patients will receive CAR-T treatment

Sponsors

Cangzhou People's Hospital
CollaboratorOTHER
Hebei Senlang Biotechnology Inc., Ltd.
Lead SponsorINDUSTRY

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
14 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

1. With the consent of himself or the legal guardian and the signed informed consent, he is willing and able to comply with the planned visit, research and treatment, laboratory examination and other test procedures; Clinical Study of CAR-T Technique in the Treatment of Recurrent and Refractory Hematopoietic and Lymphatic Tumor 2. Patients with recurrent and refractory hematopoiesis and lymphoid tissue tumors determined by clinical diagnosis; 3. Age 14-70 (including boundary value), both male and female; 4. Subjects with a physical status of 0\ 2 in the American Eastern Oncology Collaboration Group (ECOG); 5. The results of treatment related antigens were positive; 6. The expected life span is more than 3 months from the date of signing the informed consent;

Design outcomes

Primary

MeasureTime frameDescription
Safety: Incidence and severity of adverse events24 months post CAR-T cells infusionThe incidence and severity of adverse events and adverse reactions from infusion to withdrawal or before the safety follow-up period

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026