Leukemia, B-cell, Leukemia, T-Cell, Lymphoma, B-Cell, Multiple Myeloma
Conditions
Keywords
T cells
Brief summary
To evaluate the safety of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors
Detailed description
Main research objective: To evaluate the safety of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors. Secondary research objective: To investigate the efficacy and cytodynamic characteristics of autologous CAR-T cell injection in the treatment of recurrent and refractory hematopoietic and lymphoid tissue tumors
Interventions
Patients will receive CAR-T treatment
Sponsors
Study design
Eligibility
Inclusion criteria
1. With the consent of himself or the legal guardian and the signed informed consent, he is willing and able to comply with the planned visit, research and treatment, laboratory examination and other test procedures; Clinical Study of CAR-T Technique in the Treatment of Recurrent and Refractory Hematopoietic and Lymphatic Tumor 2. Patients with recurrent and refractory hematopoiesis and lymphoid tissue tumors determined by clinical diagnosis; 3. Age 14-70 (including boundary value), both male and female; 4. Subjects with a physical status of 0\ 2 in the American Eastern Oncology Collaboration Group (ECOG); 5. The results of treatment related antigens were positive; 6. The expected life span is more than 3 months from the date of signing the informed consent;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Safety: Incidence and severity of adverse events | 24 months post CAR-T cells infusion | The incidence and severity of adverse events and adverse reactions from infusion to withdrawal or before the safety follow-up period |
Countries
China