OPTIMIZATION of ADVANCED MR SEQUENCES

OPTIMIZATION of AVANCED MR SEQUENCES for BRAIN STUDIES in VOLUNTEERS (HEALTHY and PATIENTS)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05618990

Acronym

OPT-IRM

Enrollment

300

Registered

2022-11-16

Start date

2019-11-05

Completion date

2025-12-05

Last updated

2024-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Tumor, Mental Disorders, MRI, Neurosciences, Stroke

Brief summary

This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to research in clinical and cognitive neuroscience.

Detailed description

Primary goal : Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Secondary goals 1. Perform acquisitions to validate the feasibility of research MR protocols (pilot subjects) 2. reproducibility studies

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 18 ans * Covered by social security * For women in age of procreation, under efficient contraception * Written consent

Exclusion criteria

* Any MR contraindication * Claustrophobia * Pregnancy * Under judiciary protection

Design outcomes

Primary

Measure	Time frame	Description
MR sequences optimization	72 months	Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Outcome measures depend on each pulse optimized sequence (signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Secondary

Measure	Time frame	Description
Reproducibility studies	72 months	Reproducibility studies (quantitative parameters, effect of denoising ...). Outcome measures depend on each pulse optimized sequence (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).
Pilot studies	72 months	Feasibility studies in cognitive neurosciences. Outcome measures depend on each MR protocol (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

Countries

France

Contacts

Primary ContactKhaoussou SYLLA

k.sylla@ghu-paris.fr01 45 65 76 78

Backup ContactViviane AWASSI

v.awassi@ghu-paris.fr01 45 65 84 86

Outcome results