Appetitive Behavior, Glucose Metabolism Disorders (Including Diabetes Mellitus), Lipid Metabolism Disorders
Conditions
Brief summary
CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.
Interventions
DIETARY_SUPPLEMENTAcute oral CBD supplementation
1 ml hemp oil containing 300 mg CBD, within gelatin capsules, ingested orally.
DIETARY_SUPPLEMENTAcute oral placebo supplementation
1 ml hemp oil containing no CBD, within gelatin capsules, ingested orally.
Sponsors
Loughborough University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
• Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and \<30.0
Exclusion criteria
* Currently engage in \>10 hours moderate or vigorous intensity physical activity per week * Have consumed CBD or cannabis at all within the past two months * Have used CBD or cannabis regularly (\>2x in a week) within the past four months * Are suffering from any clinically significant illness * Have regularly used tobacco within the previous 6 months (\> 2/week) * Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers) * Have given a standard blood donation within 30 days of screening * Are currently pregnant or lactating * Are allergic/intolerant to any ingredients in food items provided during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy intake | ~5-30 minutes (time taken to eat a single meal) | Self-selected energy intake at an ad libitum mixed meal |
| Postprandial Glycaemia | 3 hours | Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve) |
| Postprandial Triglyceridaemia | 3 hours | Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial Insulinaemia | 3 hours | Plasma Insulin response to a mixed meal (plasma insulin concentrations and area under curve) |
Countries
United Kingdom
Outcome results
None listed