Acute Ischemic Stroke
Conditions
Brief summary
The aim of this study was to determine the differences in hemodynamics between different positions in patients undergoing ultra-early reperfusion therapy.
Detailed description
Hemodynamic stability can prevent hypoperfusion or hyperperfusion after reperfusion therapy. It has been reported in a large number of literatures that body position has an effect on hemodynamics, but the effect of different body positions on the hemodynamics of patients undergoing ultra-early reperfusion therapy is not clear. In this study, we hypothesized that the hemodynamics of patients undergoing ultra-early reperfusion therapy would differ between different positions.
Interventions
DEVICETranscranial Doppler.
Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler.
Sponsors
Yi Yang
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age≥18 years, \< 80 years, regardless of sex； * Patients with clinically confirmed acute ischemic stroke who received intravenous thrombolysis or emergency endovascular treatment; * Baseline National Institute of Health stroke scale（NIHSS）score ≤25; * Baseline Glasgow Coma Scale (GCS) ≥8; * Signed and dated informed consent is obtained
Exclusion criteria
* The patient has clear indications or contraindications, such as active vomiting, spinal cord injury； * Clinicians considered that the assigned body position could not be maintained; Patients unable to cooperate with all noninvasive beat-by-beat continuous BP monitoring; * Poor temporal window penetration; * Patients with diseases that seriously affect hemodynamics, such as atrial fibrillation, anemia, and hyperthyroidism; * Previous history of atrial fibrillation or ECG showing atrial fibrillation or arrhythmia; * Pregnant or lactating women; * Poor treatment compliance; * Complicated with severe systemic diseases, such as heart failure, respiratory failure, renal failure, gastrointestinal bleeding, coagulopathy, malignant tumors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in blood pressure variability（BPV）between different positions | 0-7 days | BPV is defined as blood pressure oscillations in relation to the mean values. |
| Differences in heart rate variability (HRV) between different positions | 0-7 days | HRV is defined as heart rate oscillations in relation to the mean values. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The difference of middle cerebral artery blood flow velocity between different positions. | 0-7 days | Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. |
Countries
China
Outcome results
None listed