Psychosis
Conditions
Keywords
social anhedonia, social reward learning, fMRI, sensitivity to reward
Brief summary
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
Interventions
BEHAVIORALMotivational Interviewing
Three motivational interviewing sessions will target sensitivity to social reward, including subjective evaluation of social interaction, socially rewarding stimuli, and events (e.g., interactions with others, feedback from others).
BEHAVIORALNutrition Didactic Training
The Nutrition didactic training will ask participants to discuss pros and cons of healthy eating habits and how to improve their current eating habits.
Sponsors
University of Alabama at Birmingham
University of California, Los Angeles
National Institute of Mental Health (NIMH)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-35 years * A first episode of a psychotic illness that began within the past three years * Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder * Taking 2nd generation antipsychotic medications * Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading * Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning * Sufficient fluency in English to comprehend testing procedures * Corrected vision of at least 20/30
Exclusion criteria
* No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis) * No evidence of moderate or severe alcohol or substance use disorder in the past 3 months * No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury * For females: no current pregnancy * No sedatives or anxiolytics on the day of assessment * No medication change 3 weeks prior to enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response Bias | 3 weeks | Response bias is defined as the likelihood of making one response, such as the frequently rewarded stimulus, more than the other response during the perceptual social reward learning task |
| the number of optimal response | 3 weeks | The number of optimal response is defined as the number of responses choosing a stimuli with optimal outcomes (e.g., choosing a good over a neutral machine or choosing a neutral over a bad machine) during the inductive social reward learning task. |
| fMRI activation levels | 3 weeks | fMRI activation is defined as beta weights from general linear model from key regions of interests including the ventromedial prefrontal cortex, dorsal anterior cingulate cortex and ventral striatum during the perceptual social reward learning task and the inductive social reward learning task. |
Countries
United States
Contacts
CONTACTJunghee Lee, PhD
CONTACTAndrew Meddaugh, BA
Outcome results
None listed