Visual Evoked Potentials
Conditions
Brief summary
Postoperative visual function injury occurs after spinal cord, neurosurgery, ophthalmology and other operations, which directly affects the postoperative quality of life of patients. Flash visual evoked potential (FVEP) is important for evaluating visual function under general anesthesia during operation. The changes of visual function can be observed and recognized in time through the amplitude changes of FVEP, which can avoid or reduce the visual function damage during operation. Anesthesia method determines the success and variability of electrophysiological monitoring to a certain extent. The purpose of this study is to investigate the effect of total intravenous anesthesia based on cyclopol on FVEP compared with propofol.
Interventions
DRUGCyclopol
Cyclopol 0.4mg/kg, sufentanil 0.2-0.4ug/kg and rocuronium 0.6mg/kg will be used for anesthesia induction. Anesthesia maintenance strategy is cyclopol 0.8-2.4 mg/kg/h and remifentanil 0.15 - 0.2 μg/kg/h
DRUGPropofol
Propofol 1-3mg/kg, sufentanil 0.2-0.4ug/kg and rocuronium 0.6mg/kg will be used for anesthesia induction. The anesthesia maintenance strategy is propofol 4-8mg/kg/h and remifentanil 0.15 - 0.2 μ g/kg/h
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Patients undergoing elective spinal surgery under general anesthesia; 2. Intraoperative electrophysiological monitoring is required; 3. 18-65 years old; 4. ASA I-III; 5. Sign the informed consent.
Exclusion criteria
1. Patients with visual impairment; 2. Patients with severe liver or kidney disease; 3. Uncontrolled hypertension, diabetes, severe arrhythmia or unstable angina pectoris; 4. Have mental illness or unable to communicate; 5. BMI≥30kg/㎡; 6. Abuse of analgesics and drug abuse history; 7. Muscle weakness, motor dysfunction or neuromuscular junction disease before operation; 8. Preoperative somatosensory dysfunction; 9. Retain trachea catheter after operation; 10. Narcotic drugs and silicone allergy; 11. Visual evoked potential monitoring was rejected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| N75-p100 amplitude of FVEP | Intraoperative |
Countries
China
Contacts
Primary ContactJiajia Ma
Outcome results
None listed