Synovitis in Patients With Osteoarthritis

Correlations Between Microscopic Features of Synovium and Clinical Parameters in Patients With Advanced Osteoarthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05617573

Enrollment

272

Registered

2022-11-15

Start date

2020-11-01

Completion date

2022-12-31

Last updated

2023-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Knee

Brief summary

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Interventions

PROCEDURETotal knee arthroplasty due to advanced osteoarthritis.

Postoperative usage of intravenous methylprednisolone

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

55 Years to 75 Years

Healthy volunteers

Inclusion criteria

* patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis.

Exclusion criteria

\- revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Design outcomes

Primary

Measure	Time frame
Correlation between pathological features and clinical scores	1 day.
Correlation between pathological features and laboratory index	1 day

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026