Adult Patients Aged 19-64, Scheduled for Elective Arthroscopic Knee Surgery
Conditions
Brief summary
This study aims to investigate whether the use of nociception monitoring during general anesthesia with remimazolam-based total intravenous anesthesia has an effect on intraoperative opioid requirements and postoperative pain. This study is a randomized trial with a 50% probability of being assigned to either group. Randomization will be done by an anesthesiologist not involved in anesthesia or postoperative outcome assessment. Patients and the investigator in charge of postoperative outcomes assessment will be blinded to group allocation.
Interventions
DEVICEAnalgesia Nociception Index monitor
Patients will receive remimazolam-based total intravenous general anesthesia with nociception monitoring with the ANI monitor
DEVICEStandard monitoring
Patients will receive remimazolam-based total intravenous general anesthesia based on hemodynamic monitoring and without nociception monitoring
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
Adult patients between 19 and 64 years of age, ASA class I\ III, scheduled for arthroscopic knee surgeryunder general anesthesia.
Exclusion criteria
Patient refusal, patients unable to read consent form, active URI or uncontrolled asthma, pneumonia, history of allergies to benzodiazepines, decreased liver or kidney function, heart failure of ejection fraction\<55%, pregnant or breastfeeding patients, history of substance abuse/addiction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative remifentanil requirement | Within the intraoperative period | Intraoperative remifentanil requirements will be collected as primary outcome as µg/kg/min |
Countries
South Korea
Contacts
Primary ContactSeokyung Shin
Outcome results
None listed