Crohn Disease, Ileocecal; Lesion, Microtia
Conditions
Brief summary
In this study, the microbiota sequencing was used to investigate the changes of microbiota in the terminal ileum and the middle part of ascending colon, the mesenteric adipose tissue of ileum and ascending mesocolon, and oral cavity of patients with Crohn's disease before and after ileocecal resection, so as to further explore the role of ileocecal region in inducing remission of disease.
Interventions
None listed
Sponsors
Shanghai 10th People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Clinical diagnosis of Crohn's disease
Exclusion criteria
Serious oral diseases (e.g. dental caries, periodontal disease) Other acute or chronic gastrointestinal diseases Probiotics or prebiotic consumption and antibiotic use within 1 month
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microbial changes of intestinal mucosa | 6 month | Explore the microbial changes in the mucosa of the terminal ileum and the middle segment of the ascending colon in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microbial changes of mesenteric adipose tissue | 6 month | Explore the microbial changes in the mesenteric adipose tissue of the terminal ileum and the middle segment of the ascending colon in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis |
Other
| Measure | Time frame | Description |
|---|---|---|
| Microbial changes of oral cavity | 6 month | Explore the microbial changes in the buccal region of oral cavity in patients with Crohn's disease before and after ileocecal resection through metagenomic analysis |
Countries
China
Contacts
Primary ContactKai Xia, MM
Backup ContactRenyuan Gao, MD
Outcome results
None listed