Healthy Volunteers
Conditions
Keywords
High-Definition Transcranial Direct Current Stimulation, HD-tDCS, functional Magnetic Resonance Imaging, Attentional control, Attention Network Test
Brief summary
In a randomized, triple-blind, sham-controlled clinical trial, we will assess the effect of a single session frontal cortex High-Definition transcranial Direct Current Stimulation (HD-tDCS) on brain activity and functional connectivity underlying the behavioral change in attentional control in healthy participants. Participants will be recruited after meeting the inclusion criteria and will be randomly assigned to active or sham stimulation groups. All participants will undergo resting-state functional Magnetic Resonance Imaging (rsfMRI) scan and perform an Attention Network Test (ANT) in a functional Magnetic Resonance Imaging (fMRI) scanner before and after receiving a single session of active or sham HD-tDCS.
Interventions
Portable multi-channel tES stimulation (Starstim 8, Neuroelectric, Barcelona, Spain) will be used.
Portable multi-channel tES stimulation (Starstim 8, Neuroelectric, Barcelona, Spain) will be used.
Sponsors
University of Tehran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
Triple-blind study
Intervention model description
Participants are allocated to one of two conditions: Active or Sham.
Eligibility
Sex/Gender
ALL
Age
20 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* Right-handed healthy adults * Age range 20-39 years * Normal or corrected-to-normal vision * Willing and capable of following study protocol requirements given in the informed consent
Exclusion criteria
* Psychiatric conditions (e.g., depression and generalized anxiety disorder, etc.) * Medical illness or neurological disorder (e.g., cardiovascular illness, anemia, respiratory illness, neurological illness, seizure, etc.) * Current abuse of drugs or alcohol * Any conditions that prevent undergoing an fMRI scan or tDCS stimulation according to the fMRI and tDCS safety checklists
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Attention Network Test (ANT) performance before and after the intervention (active versus sham HD-tDCS) | Immediate before and immediate after intervention |
| Change in resting state functional connectivity before and after the intervention (active versus sham HD-tDCS) | Immediate before and immediate after intervention |
| Change in task-based functional connectivity during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS) | Immediate before and immediate after intervention |
| Change in the blood-oxygen-level-dependent (BOLD) signal during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS) | Immediate before and immediate after intervention |
Secondary
| Measure | Time frame |
|---|---|
| Side effect checklist for transcranial Direct Current Stimulation (Reported as Yes or No) | One day after simulation session |
Countries
Iran
Contacts
Primary ContactFaculty of Psychology
Outcome results
None listed