Renal Nerve Denervation(RDN) and Renal Function

Effect of RDN on Renal Function

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05612906

Enrollment

Registered

2022-11-10

Start date

2022-06-01

Completion date

2026-12-01

Last updated

2025-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of RDN on Renal Function

Brief summary

Current studies have found the efficacy of RDN in the treatment of hypertension, however, the safety of RDN in renal function is still lacking. Therefore, the investigators are aimed to study the effect of RDN on renal function.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

1.18\<age≤75 years; 2.clinic blood pressure ≥ 140/90 mmHg or 24-hour ambulatory blood pressure monitoring average blood pressure ≥ 135/85 mmHg after taking 3 or more antihypertensive drugs for more than 4 weeks; 3.essential hypertension, renal parenchymal hypertension, or hypertension patients who are willing to receive RDN ; 4.who signed informed consent and were approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University.

Exclusion criteria

* pregnant women or lactating patients; * identified secondary hypertension or Pseudo hypertension; * whose renal arteries were unsuitable for ablation * obvious bleeding tendency and blood system diseases; * malignant tumors or end-stage diseases; ⑥Severe peripheral vascular disease, abdominal aortic aneurysm; ⑦A history of the acute coronary syndrome within two weeks; ⑧acute or severe systemic infection; ⑨drug or alcohol dependence or refusal to sign informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Changes of serum creatinine and urea nitrogen before and after RDN operation	Baseline,1week/1 month/6months after RDN operation	Serum creatinine(umol/L, ammonia iminohydrolase assay)and urea nitrogen(umol/L, urease methods) were obtained by blood test.
Changes of glomerular filtration rate before and after RDN operation	Baseline, 6months after RDN operation	Glomerular filtration rate(ml/min) were obtained by ECT

Secondary

Measure	Time frame	Description
Effect of RDN operation on renal artery	Baseline, 6months after RDN operation	Renal arteries were observed by CT angiography.
Urinary protein/serum creatinine ratio change before and after RDN operation	Baseline,1week/1 month/6months after RDN operation	Urinary protein (mg/L, PRM assay) were tested by urine test.Serum creatinine(umol/L, ammonia iminohydrolase assay) were obtained by blood test.

Countries

China

Contacts

Primary ContactZhengrong Huang, M.D.

huangzhengrong@xmu.edu.cn+8613606028353

Outcome results