Post-stroke Depression
Conditions
Brief summary
This study aims to investigate effects of transcranial current stimulation (tES) and transcutaneous direct current stimulation (tsDCS) associated changes on fronto-parietal EEG and cognitive performance in patients with post stroke depression (PSD)
Detailed description
The investigators will perform a double blind, randomized, sham controlled, crossover study design to assess effects of tES, tsDCS and sham stimulation on the performance during a cognitive control task. The working Hypothesis is tsDCS and/or tES will enhance frontal theta oscillations as recorded on EEGs and improve task performance compared to sham stimulation. Results from this project can potentially lead to the development of a new research tool for assessing neuromodulation strategies to treat mental disorders and their comorbidities. It will also uncover the neural correlates of cognitive deficits in PSD and provide feasible biomarkers associated with treatment response in support of a larger clinical.
Interventions
PROCEDURETranscranial Electrical stimulation
Noninvasive electrical stimulation of lateral frontal cortex.
PROCEDURETranscutaneous direct current stimulation
Noninvasive electrical stimulation of the T10 spinal column.
Sponsors
University of Cincinnati
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Subjects will include both male and female of age over 18 years and a BMI of 18-35 Kg/mts2 who have experienced stroke. 2. Moderately depressed, MADRS:18-28, PHQ9: 10-20 and/or experiencing cognitive impairments after stroke
Exclusion criteria
1. Current or lifetime bipolar disorder or schizophrenia diagnosis; 2. current (past month): PTSD, psychotic or substance use disorder (nicotine and caffeine allowed); 3. significant risk of suicide according to CSSRS or clinical judgment, or suicidal behavior in the past year: 4. current chronic severe pain conditions; 5. current chronic use of: opioids analgesics, medications that affect blood pressure or drugs with significant autonomic effects (stimulants and antipsychotics allowed if dose stable for 1 month); 6. skin lesions on electrode placement region; 7. implanted electrical medical devices; 8. Pregnancy; 9. suspected IQ\<80, and 10) any other clinically relevant reason as judged by the clinician.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG oscillations | change from baseline | Theta (4-8 Hz) oscillations in the mid frontal EEG |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Behavior | during procedure | Response time in a multi source interference task |
Countries
United States
Outcome results
None listed