Esophagogastric Cancer
Conditions
Keywords
Tooth erosion, GERD, Loss of tooth enamel, 22-370
Brief summary
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.
Interventions
OTHERSurvey
This is a 15-item questionnaire. The questionnaire asks subjects to quantify, during a specified duration of time, the number of times they have consumed or completed a task (ex. alcohol intake, cigarette use, and teeth brushing frequency). Additionally, the questionnaire further asks subjects to quantify their GERD symptoms and risk factors prior to diagnosis. All study procedures will be completed in one visit as part of a standard-of-care clinic visit.
OTHERIntra-oral camera
Intraoral pictures of molars and incisors in 13 key regions
OTHEROptional Salvia sample
Cohort 1 only. Participant is responsible for collecting and bringing the salvia sample to clinic.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Patients will complete a questionnaire and undergo imaging by the intra-oral camera of their teeth.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subject is willing and able to provide written informed consent. * Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls * Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera. * Patients must be able to understand English language or have access to adequate translation services. * Age ≥ 18 years old.
Exclusion criteria
* Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants. * For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of dental erosions | 1 year | scored with a modified BEWE index. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORSteven Maron, MD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed