Drinking, Alcohol
Conditions
Keywords
alcohol, attention, TMS, binge drinking, emotion, social cognition, moral, MRI, frontal eye fields, moral cognition
Brief summary
The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol. Participation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan. People in the Auburn/Opelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.
Interventions
DEVICETMS
TMS will be administered in a pattern that is either excitatory or inhibitory.
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Auburn University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
Participants will be randomly assigned to receive each arm in counterbalanced order (AB or BA).
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1\. Age 18 or Older 2A. (Drinker Group): Reports consuming 4 \[if female\]/ 5 \[if male\] or more standard drinks on one occasion at least 2 times a month AND/OR reports consuming more than 7 \[if female\]/ 14 \[if male\] standard drinks per week on average 2B. (Healthy Volunteer Group): Reports consuming 4 \[if female\]/ 5 \[if male\] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 \[if female\]/ 14 \[if male\] standard drinks per week on average
Exclusion criteria
1. MRI Contraindications 1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos) 2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr 3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS 2. TMS Contraindications 1. Has ever had a seizure, or has a family history of epilepsy 2. Taking medications or substances that lower the seizure threshold\* 3. Implanted devices that are in the head or rely on physiological signals 4. History of neurological disease, such as stroke or brain tumor 5. Head injury with loss of consciousness greater than 30 minutes 6. Actively withdrawing from alcohol 3. Family history of schizophrenia or presence of psychotic symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in attention switching | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of behavioral data |
| Change in sociomoral attention switching | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of behavioral data |
| Change in cue reactivity | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of behavioral data |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in brain activity attention switching | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of imaging (fMRI) data |
| Change in brain activity during sociomoral attention switching | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of imaging (fMRI) data |
| Change in brain activity during cue reactivity | Baseline, immediately following TMS A, immediately following TMS B | MRI Task- analysis of imaging (fMRI) data |
Countries
United States
Contacts
Primary ContactSCAMPI Lab
Outcome results
None listed