Blood Pressure, Cardiovascular Diseases, Endothelial Dysfunction, Intermittent Claudication, Peripheral Arterial Disease
Conditions
Brief summary
The aim of this study is to analyze acute responses of arm-cranking exercise on cardiovascular function of peripheral arterial disease patients and compare it to the main exercise recommendation, walking exercise.
Detailed description
Twenty patients with peripheral arterial disease and claudication symptoms will be recruited. The patients will perform three experimental conditions, in randomized order (walking, arm-cranking and control). The exercise conditions will be composed of 15 bouts of 2 minutes exercise with an intensity equivalent to 13-15 on Borg's Subjective Perceived Exertion Scale. During the experimental conditions (walking, arm-cranking and control) blood pressure, heart rate and cerebral blood velocity will be evaluated, along with perceived exertion and affective responses. Before and after experimental conditions, vascular function, blood pressure, heart rate variability, cerebral blood velocity, subjective perceived exertion and affective responses will be evaluated.
Interventions
BEHAVIORALExercise
Three conditions will be tested: Walking, arm-cranking and control condition.
Sponsors
University of Nove de Julho
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
The outcomes assessor is blind for the condition performed by the patients.
Intervention model description
The patients will perform three experimental conditions, in randomized order (walking, arm-cranking and control). The exercise conditions will be composed of 15 bouts of 2 minutes exercise with an intensity equivalent to 13-15 on the Borg's subjective perceived exertion scale.
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Peripheral arterial disease diagnosis; * Age ≥ 40 years old; * If a woman, be in menopause without the use of hormone replacement therapy; * Do not be an active smoker; * Be apt to perform exercise.
Exclusion criteria
* Any change in medication; * Any health impairment that contraindicates the practice of physical exercise.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in vascular function post-exercise in the brachial and femoral arteries. | Change from baseline at post-intervention, after 20 minutes. | Vascular function will be measured in the supine position by the flow-mediated dilation (FMD) technique, through Doppler ultrasonography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in blood pressure post-exercise. | Change from baseline at post-intervention, after 10 minutes. | Blood pressure will be measured by an automatic monitor. |
| Change from baseline in heart rate variability post-exercise. | Change from baseline at post-intervention, after 30 minutes. | Autonomic modulation of the cardiovascular system will be measured by the heart rate variability (HRV) technique, by a heart rate monitor valid for this function. |
| Change from baseline in cerebral blood velocity post-exercise. | Change from baseline at 35 minutes after the beginning of the exercise. | Cerebral blood velocity will be measured by a transcranial doppler ultrasound. |
Countries
Brazil
Outcome results
None listed