Intrathecal Prilocaine and Adductor Canal Block vs Intrathecal Bupivacaine Alone for Ambulatory Knee Arthroscopy

Hybrid Anesthesia for Ambulatory Knee Arthroscopy Using Intrathecal Prilocaine and Adductor Canal Block vs Intrathecal Bupivacaine Alone: a Randomized Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05609565

Enrollment

Registered

2022-11-08

Start date

2022-11-15

Completion date

2024-09-30

Last updated

2024-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain

Brief summary

\- Although bupivacaine is safe and has a low rate of transient neurologic symptoms, the prolonged sensory and motor block is a drawback for day-case spinal anesthesia.Intrathecal hyperbaric prilocaine causes a much shorter motor block, with a similar onset time and lower inter-individual variability in motor block duration. Furthermore, the peripheral nerve block is used as an adjunct to the spinal anesthesia to prolong the surgical anesthetic conditions.

Interventions

DRUGspinal anesthesia with hyperbaric prilocaine+adductor canal block (ACB) with bupivacaine

spinal anesthesia with hyperbaric prilocaine+adductor canal block (ACB) with bupivacaine

DRUGspinal anesthesia with bupivacaine

spinal anesthesia with bupivacaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

21 Years to 60 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists (ASA) score I-II. * Body mass index \< 35 kg/m2

Exclusion criteria

* Patient's refusal. * Known coagulopathy. * Known peripheral neuropathy or neurological deficits. * Known allergy to study drugs.

Design outcomes

Primary

Measure	Time frame	Description
The duration of motor block (minutes)	24 hours postoperatively	The duration of motor block (minutes)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026