Endothelial Glycocalyx Damage in Brain Death Organ Donors

Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05609123

Enrollment

100

Registered

2022-11-08

Start date

2022-01-01

Completion date

2027-12-31

Last updated

2026-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Damage Due to Hypoxia, Organ Donors, Organ Transplant Failure or Rejection

Brief summary

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Interventions

DIAGNOSTIC_TESTEndothelial glycocalyx damage assessment

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients in critical condition declared as brain dead by clinical examination

Exclusion criteria

* N/A

Design outcomes

Primary

Measure	Time frame	Description
Markers of endothelial glycocalyx damage	baseline at the time of inclusion	Levels of syndecan-1 in serum and urine

Countries

Czechia

Contacts

CONTACTDavid Astapenko, MD, PhD

david.astapenko@fnhk.cz+420495833218

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026