Anomia, Epilepsy, Temporal Lobe Epilepsy
Conditions
Brief summary
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis. The primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.
Interventions
PROCEDURESpeech therapy
Patients will connect on an interface to pratice speech therapy
PROCEDURESpeech therapy assessment
Patients will be followed by an speech therapist
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patient 16 years of age and older, 2. Patient whose epileptogenic area involves the temporal structures of the hemisphere specialized for language, 3. Patient whose hemispheric specialization for language is known 4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or resection in the temporal lobe involving the hippocampus and/or the baso-temporal language area and whose planned surgery date is compatible with the performance of the study, 5. Patient with a known NTB score 6. Patient who has signed an informed consent or patient whose parents or legal guardians have signed the informed consent (or a single parent or legal guardian if applicable) 7. Patient whose first language is French (1st language learned by the patient), 8. Patient declaring to be familiar with the use of a computer and having access to an internet connection from home 9. Patient affiliated or benefiting from a social security system.
Exclusion criteria
1. Patient with a speech disorder that may impair intelligibility and compromise the use of the interface; 2. Patient with an uncorrected hearing impairment, 3. Patients with a total intelligence quotient (IQ) \<70 (assessed in the context of care, in the year preceding the surgical procedure) 4. Patients who are pregnant, nursing, deprived of liberty, under guardianship or curatorship.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of rehabilitation on immediate postoperative performances | Day 7 after surgery | Number of images quoted |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impact of rehabilitation on immediate on standardized language tests | Day 7 after surgery | % of correct answers of language tests |
| Impact of rehabilitation on long-term postoperative performance on standardized language tests | 6 months after surgery | % of correct answers of language tests |
| Impact of preoperative rehabilitation on verbal memory | Day 7 after surgery | Verbal memory task |
| Lexical fluency | Day 7 after surgery | Lexical evocation tests limited to 2 minutes according to a formal criterion or an imposed categorical criterion |
| Impact of rehabilitation on long-term postoperative performance | 6 months after surgery | Number of images quoted |
| Self-reported perception of anomia | Day 7 after surgery | Use of an ad-hoc scale graduated from 0 (no complaint) to 10 (maximum complaint) |
| Evaluation of Quality of life | Day 7 after surgery | Quality Of Life in Epilepsy Inventory (QOLIE-31) (0 meaning better outcome, highest score meaning worse outcome) |
| Impact of pre-operative rehabilitation on the number of post-operative rehabilitation sessions | 6 months after surgery | Number of speech therapy sessions performed postoperatively |
| Denomination of control lists | Day 7 after surgery | Number of words quoted |
Countries
France
Contacts
Primary ContactVeronique Sabadell
Outcome results
None listed