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COVID-19 Bivalent Booster Megastudy

COVID-19 Bivalent Booster Megastudy

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05607082
Enrollment
2600000
Registered
2022-11-07
Start date
2022-11-03
Completion date
2023-02-06
Last updated
2023-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19

Keywords

COVID-19 vaccination, behavioral science interventions, vaccination promotion

Brief summary

This megastudy is a massive randomized controlled trial. By randomizing participants to 10 different intervention conditions simultaneously, the investigators will be able to compare the effectiveness of different interventions to one another and to a control group (in which individuals will only receive the usual communications from their partner organization) to identify which interventions significantly increase vaccination rates. Pharmacy customers will be randomly assigned to receive one of the interventions designed by team scientists to encourage vaccination or to a control group. The baseline intervention will be based on the top-performing SMS intervention identified in the investigators previous megastudies on encouraging vaccination (Milkman et al., 2021b, 2022). Pharmacy customers will receive SMS messages conveying that a COVID booster vaccine is reserved or waiting for them at the pharmacy. Additional behavioral science messaging strategies will be tested by building off of this baseline intervention.

Interventions

Participants will receive text messages per descriptions listed in the arms.

Sponsors

University of Pennsylvania
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Caregiver, Outcomes Assessor)

Masking description

As treated participants will receive text messages, there is no scope for blinding. Care providers will not be made aware of subjects' participation in the study, or assigned treatment arms. The study team will only receive data on subjects' assigned arms and outcomes at the end of the study.

Intervention model description

Participants will be randomly assigned to the different arms.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

• Patient of a large retail pharmacy that has opted into receving SMS messages from the pharmacy and has received their primary COVID vaccination series.

Exclusion criteria

* The patient unsubscribed from texts before the send date and time of the patient's SMS/MMS message * The patient received a bivalent COVID booster before the send date and time of the patient's SMS/MMS message.

Design outcomes

Primary

MeasureTime frameDescription
Patient uptake of the COVID bivalent boosterDuring the 30 days after receiving the SMS/MMS interventionWhether patients receive a bivalent COVID booster at the pharmacy in question

Secondary

MeasureTime frameDescription
Patient uptake of the COVID bivalent booster60 days after receiving the SMS/MMS interventionWhether patients receive a bivalent COVID booster at the pharmacy in question

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026