Effects of Blood Flow Restriction During Eccentric Resistance Exercise

Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05606744

Enrollment

Registered

2022-11-07

Start date

2023-06-01

Completion date

2024-03-01

Last updated

2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Flow Restriction

Brief summary

The purpose of this study is to compare the muscle strength and muscle soreness effects experienced following short term (acute) eccentric exercise with and without blood flow restriction (BFR) performed at low - moderate training intensities.

Interventions

DEVICEEccentric exercise / Eccentric exercise with blood flow restriction

Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Investigator)

Intervention model description

Individuals will be randomly assigned to a BFR or non BFR exercise condition. The subjects will perform a single, 3-5 minute bout of eccentric exercise on the Eccentron device either with BFR (with restriction cuffs on the thigh per the procedures below) or without the BFR.

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Exclusion criteria

* lower body surgery or injury in the last 12 months * have any neuromuscular disease * height \>76 inches tall * height \<54 inches tall * eccentric strength greater than 725 pounds * pregnant or plan to be pregnant in the duration of the protocol * don't do resistance exercise at least once per week * perform intense cardio or strength training \>4 days per week * Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing Inclusion criteria: * 18 - 30 years old * strength train lower body 1-3 times per week

Design outcomes

Primary

Measure	Time frame	Description
visual analog scale (soreness)	Baseline (pretest)	soreness
force algometer (soreness)	Baseline (pretest)	soreness

Secondary

Measure	Time frame	Description
Eccentric muscle strength	Baseline (pretest)	muscle strength will be assessed on the Eccentron.
Single-leg hop	Baseline (pretest)	3 single-leg hops per limb

Contacts

Primary ContactBrennan J Thompson, PhD

brennan.thompson@usu.edu435-797-5785

Backup ContactSara Harper, PhD

sara.harper@usu.edu435-797-1376

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026