Eosinophilic Esophagitis
Conditions
Brief summary
This research is being done to see if patients with milk-triggered EoE are able to tolerate baked milk in their diet and if there is a threshold amount of straight milk that is tolerable.
Interventions
DIETARY_SUPPLEMENTBaked Milk
Participants to regularly eat a baked milk muffin for 6 weeks
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with Eosinophilic esophagitis ≥ 15 eosinophils per HPF * Going through or completed the six-food elimination diet, with milk only or milk plus one additional food identified as a trigger
Exclusion criteria
* Patients with conditions known to be associated with esophageal eosinophilia, including Crohn's disease, Churg-Strauss, achalasia, and hypereosinophilic syndrome * Topical swallowed steroids within 8 weeks of study enrollment * Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Histological remission | 6 weeks | Number of patients in histologic remission at the end of a 6 week trial of baked milk. Histologic remission is defined by \<15 eos per HPF on cytosponge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptomatic remission | 6 weeks | Number of patients in symptomatic remission after a 6 week trial of baked milk. Symptomatic remission is defined by EEsAI PRO score of \<20 |
Countries
United States
Outcome results
None listed