Long COVID
Conditions
Brief summary
Pain is among the most frequently reported symptoms in Long COVID, along with sleep disturbances, fatigue, and cognitive impairments. Sleep plays a critical role in maintaining a pain-free state. The goal of this study is to characterize the type and severity of pain in Long COVID, to characterize sleep and sleep disturbances in Long COVID, and to understand the role of sleep in the development and persistence of pain symptoms in Long COVID.
Interventions
OTHERNo intervention
Observational, no intervention
Sponsors
Beth Israel Deaconess Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Females and males \>18 years * Confirmed history of SARS-CoV-2 infection
Exclusion criteria
* History of chronic pain prior to SARS-CoV-2 infection * Raynaud syndrome * Pregnant/nursing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain reporting | 14 days | Daily pain severity reporting on rating scale from 0 to 10 (greater values indicate greater pain) |
| Pain sensitivity | 1 day | Pain thresholds to mechanical and temperature stimuli measured in kPa (pressure) and Celsius (heat). Lower values indicate lower pain thresholds. |
| Central pain modulation | 1 day | Capacity of the CNS to modulate pain |
| Wearable based sleep characteristics | 2 weeks | Estimation of sleep duration, fragmentation, regularity based on actigraphy |
| PSG based sleep characteristics | 1 day | Sleep stages and architecture based on PSG |
Countries
United States
Outcome results
None listed