Breast Cancer, Diet, Healthy, Immune Deficiency
Conditions
Keywords
Aerobic exercises, Diet therapy, Immune function, Mastectomy
Brief summary
The purpose of the study was to investigate the impact of aerobic exercise combined with diet protocol on the immune system in post-mastectomy patients receiving chemotherapy.
Detailed description
Chemotherapy reduces circulating lymphocytes levels, which affect lymphocytes in breast cancer patients during the therapy itself or up to 3 months after the last chemotherapy cycle, so the study is developed to investigate the impact of aerobic exercise combined with diet protocol on the immune system in post-mastectomy patients receiving chemotherapy. Sixty post-mastectomy women were receiving chemotherapy and aged from 40-60 years selected from the outpatient clinic of the oncology department in the New Cairo hospital in the Police Academy. They will be assigned randomly into three equal groups, the aerobic exercises and diet protocol group, the diet protocol group, and the aerobic exercises group. The immunological markers; total lymphocyte count (TLC), neutrophil-to-lymphocyte ratio(NLR), and platelet-to-lymphocyte ratio(PLR) will be measured at baseline and after twelve weeks of intervention.
Interventions
OTHERAerobic exercises
Aerobic exercise by using the treadmill, two times per week. Its intensity was equivalent to 60-85% of each patient's maximum heart rate and lasted 20 minutes in the first week and 30 minutes in weeks 2-12.
OTHERDiet protocol
A specific diet for three months is designed to boost the immune system through edible seeds and nuts which are rich in proteins, fats, fibers, minerals, and vitamins.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Computer randomization.
Intervention model description
The model is composed of the aerobic and diet protocol group (Group A), the diet protocol group (Group B), and the aerobic training group (Group C).
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Female post-mastectomy patients. * Age range is between 40-60 years old. * All patients will enter the study after having their informed consent. * All patients are undergoing chemotherapy treatment with AC protocol (Adriamycin with endoxan) for four cycles (every 21 days ). * All patients have finished the first stage of chemotherapy treatment
Exclusion criteria
* Cardiac disease patients. * Uncontrolled hypertension patients. * Patients with thyroid disease. * Patients with lymphatic complications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change in total lymphocyte count. | Baseline and twelve weeks after the intervention. | from patient's blood sample analysis for immunological markers in lab. |
| The change in neutrophil to lymphocyte ratio. | Baseline and twelve weeks after the intervention. | from patient's blood sample analysis for immunological markers in lab. |
| The change in platelet to lymphocyte ratio. | Baseline and twelve weeks after the intervention. | from patient's blood sample analysis for immunological markers in lab. |
Countries
Egypt
Contacts
Primary ContactShaimaa MA Elsayeh, PhD
Outcome results
None listed