Gram-negative Bacteremia, Gram-Positive Bacteremia, Sepsis
Conditions
Brief summary
The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU) patients. The main question it aims to answer is: what serum level of PCT and CRP is predictive of gram+ and gram- sepsis in patients with positive blood cultures in the surgical ICU. The study will be retrospective and will include all patients with positive blood cultures who were hospitalized in the surgical ICU of University Hospital Osijek in the period from January 2019 to May 2022.
Detailed description
PCT is a good biochemical marker of severe bacterial infection. Numerous studies have confirmed its role in the diagnosis of sepsis, especially sepsis with positive blood cultures. This retrospective study will include septic patients who were hospitalised in the surgical ICU between January 2019 and May 2022, and who had at least one positive blood culture. The values of PCT, CRP, white blood cells count and platelets count, as well as the overall outcome of the treatment, will be recorded for the patients included in the research. The aim of the research is to examine the differences in the level of PCT, CRP, white blood cells count and platelets count between patients with gram+ and gram- blood cultures. Also, the predictive value of PCT and CRP in differentiating gram+ from gram- hem will be examined.
Interventions
DIAGNOSTIC_TESTWhite blood cell count
All patients will have their white blood cell (WBC) count recorded on the day of the positive blood culture and in the next three days.
DIAGNOSTIC_TESTPCT levels
All patients will have their serum PCT level recorded on the day of the positive blood culture and in the next three days.
DIAGNOSTIC_TESTCRP levels
All patients will have their serum CRP level recorded on the day of the positive blood culture and in the next three days.
DIAGNOSTIC_TESTPlatelet count
All patients will have their platelets count recorded on the day of the positive blood culture and in the next three days.
Sponsors
Osijek University Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* hospitalisation in surgical ICU * diagnosis of sepsis * gram+ blood culture isolate * gram- blood culture isolate
Exclusion criteria
* younger of 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictive level of PCT | 4 days | Predictive serum level of PCT in differentiating gram+ from gram- blood culture |
| Predictive level of CRP | 4 days | Predictive serum level of CRP in differentiating gram+ from gram- blood culture |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| White blood cells count | 4 days | Test for differences in WBC count between patients with gram+ and gram- blood cultures |
| Platelets count | 4 days | Test for differences in platelets count between patients with gram+ and gram- blood cultures |
| PCT levels and outcome | 4 days | To examine differences in serum PCT levels between patients who survived and those who died |
| CRP levels and outcome | 4 days | To examine differences in serum CRP levels between patients who survived and those who died |
Countries
Croatia
Outcome results
None listed