Aortic Aneurysm, Aortic Disease, Aortic Stenosis, Large Artery Stiffness
Conditions
Keywords
aortic disease, large artery stiffness, aortic stenosis, aortic aneurysm
Brief summary
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease
Interventions
prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms
Sponsors
Heinrich-Heine University, Duesseldorf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. apparently healthy volunteers Inclusion Criteria: • Healthy volunteers
Exclusion criteria
* \< 18 years * Active Medication * Cardiovascular Disease * MRI not possible 2. Patients with Aortic Stenosis Inclusion Criteria: • Patients suffering from 3rd drgree Aortic Stenosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progressive accelerated Large Artery Stiffening | 5 years | measured by CMR |
| Development of Aortic Aneurysm | 5 years | measured by CMR |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic Dysfunction | 5 years | measured by CMR |
| Ejection Rate and Ejection Time | 5 years | measured by CMR |
| Flow encoded regional MRI metrics | 5 years | measured by CMR |
Countries
Germany
Contacts
Primary ContactChristine Quast, MD
Backup ContactLisa Dannenberg, MD
Outcome results
None listed