Heart Failure
Conditions
Brief summary
Heart failure (HF) affects about 1% of patients younger than 55 years, whereas the prevalence of HF increases \> 10% in patients with at least 70 years of age. Despite HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the clinical significance of HF with mildly reduced ejection fraction (HFmrEF) has gained more importance within the past years. Those patients are characterized by a left ventricular ejection fraction (LVEF) of 41-49%. However, within the current European guidelines, limited treatment recommendations in this subgroup of HF are yet available as a consequence of the limited number of studies in this field. The Heart Failure With Mildly Reduced Ejection Fraction Registry aims to characterize patients with HFmrEF and investigated the prognostic impact of interventional and pharmacological therapies in this subgroup of HF patients.
Interventions
None listed
Sponsors
Universitätsmedizin Mannheim
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with HFmrEF (i.e., LVEF 41-49%) * Patients with at least 18 years of age
Exclusion criteria
* Patients younger than 18 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 2 years. | All-cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of LVEF | 2 years. | Change of LVEF |
| Change of NT-pro BNP | 2 years. | Change of NT-pro BNP |
| Heart-failure related hospitalization | 2 years. | Heart-failure related hospitalization |
Countries
Germany
Contacts
Primary ContactMichael Behnes, MD
Outcome results
None listed